Multiscale structure-function relationships in the lungs

Whole Organ Scale

Quantifying total respiratory system behavior: pressure-flow-volume dynamics, system identification, closed-loop control, mechanical ventilation strategies, oxygen and carbon dioxide monitoring.

Regional Parenchymal Scale

Quantifying spatial distributions of structure and function: dynamic 4DCT and 5DCT imaging, xenon-CT ventilation imaging, iodine dual-energy CT perfusion imaging.
 

Alveolar Scale

Quantifying alveolar response to ventilation: dissection, micro-ventilation, dynamic light microscopy and micro-CT imaging, computational modeling, alveolar inflation instability, alveolar interdependence.

Protein Fiber Scale

Quantifying mechanical properties of fibers and fiber networks: decellularization, fiber isolation, enzymatic degradation, microscale tensile testing, multiphoton microscopy, scanning electron microscopy.